作 者 |
Jong-Yueh Lin, Fong-Fu Chou, Ting-Lung Lin, Kun-Chou Hsieh, Ya-Ling Yang |
英文摘要 |
Objective: A prospective, randomized, double-blind study was conducted to
investigate the efficacy of dexamethasone in the prevention of postoperative nausea
and vomiting (PONV) in patients who underwent thyroid or parathyroid surgery,
when combined with morphine injection at the end of general anesthesia.
Methods: One hundred and twenty-two patients between 14 and 79 years old were
included in this study. Group I (N=80) consisted of patients who received
dexamethasone (10 mg) before induction, and Group II (N=42) consisted of those
who received placebo (normal saline, 10 ml) before induction. Thirty-nine patients in
group I were given morphine (5 mg) by the anesthetists, before the end of general
anesthesia. At 4 hr and 24 hr after surgery, the sensation of nausea and the incidence
of vomiting were assessed.
Results: At 4 hr after surgery, the sensation of nausea and incidence of vomiting
were significantly higher in Group II than in Group I without morphine injection
(P=0.009 and P=0.010, respectively) and significantly higher in patients receiving
morphine than in patients without morphine of Group I (P=0.026 and P=0.008,
respectively).
Conclusions: Preinduction with dexamethasone (10 mg) infusion can decrease
PONV at 4 hr after surgery if morphine is not used, but dexamethasone infusion in
conjunction with morphine injection before the end of general anesthesia does not
decrease PONV. |
